Infection in rheumatoid disease.

Changes in Glycosylation of Alpha-1-Protease Inhibitor in Inflammation (Rheumatoid Arthritis and Crohn\'s Disease)

Alpha-1-proteinase inhibitor (API) is one of the acute phase proteins. Following an inflammatory stimuli the concentration of API increased up to four folds. Accompanying these quantitative changes, there is qualitative alterations in the structure of carbohydrate moiety (glycosylation). To determine the alterations in the glycosylation of API in inflammation, API was isolated from the sera of...

Mortality in rheumatoid disease.

This paper provides an overview of rheumatoid disease from the perspective of its impact on mortality. The term, rheumatoid arthritis, may promote the misconception that this disease is relatively trivial and easily managed; therefore, "rheumatoid disease" is preferred. Numerous long-term studies in many settings have established that significant excess mortality is associated with rheumatoid d...

Haemodilution in rheumatoid disease.

It has been suggested (Robinson, 1943; Dixon, Ramcharan, and Ropes, 1955) that the plasma volume in rheumatoid disease is greater than normal and that this increase may produce anaemia by dilution of the red cell mass. Such a mechanism might account for the refractory anaemia which sometimes occurs and in which there is a proportionate reduction of red cells and haemoglobin in the peripheral bl...

Depression in rheumatoid disease.

In a disease in which the patient is continually subjected to pain and forced to face the probability of increasing deformity and handicap, the occurrence of a depressive reaction might be expected. (Symposium, 1968). It has been suggested that many patients suffering from rheumatoid disease experience a depressive reaction which may materially impede progress and delay rehabilitation (Leading ...

Malabsorption in rheumatoid disease.